Observe Intently (one)pentobarbital will decrease the extent or outcome of osilodrostat by influencing hepatic/intestinal enzyme CYP3A4 metabolism.
fentanyl iontophoretic transdermal system and pentobarbital both boost sedation. Stay away from or Use Alternate Drug. Limit use to individuals for whom substitute treatment method possibilities are insufficient
pentobarbital will minimize the extent or effect of pantoprazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importance Unknown.
pentobarbital will minimize the level or effect of pioglitazone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Importance Unfamiliar.
pentobarbital will lessen the level or impact of mavacamten by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.
pentobarbital will lessen the level or result of methadone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.
Observe Carefully (1)pentobarbital will lessen the level or effect of exemestane by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check. For patients getting exemestane which has a potent CYP3A4 inducer the advisable dose of exemestane is fifty mg daily after a food.
pentobarbital improves effects of ifosfamide by affecting hepatic enzyme CYP2B6 metabolism. Use Caution/Keep track of. Coadministration of ifosfamide with CYP2B6 inducers could boost metabolism of ifosfamide to its metabolite. Observe for amplified effects/toxicities if combined with CYP2B6 inducers.
pentobarbital will lessen the extent or impact of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Significance Unidentified.
pentobarbital will decrease the level or impact of rabeprazole by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Significance Not known.
pentobarbital will reduce the extent or effect of lonafarnib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Lonafarnib is really a delicate CYP3A4 substrate. Coadministration with powerful or moderate CYP3A4 inducers is contraindicated.
pentobarbital will minimize the extent or effect of cinacalcet by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
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Watch Intently (1)pentobarbital will minimize the level or outcome of fentanyl by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Carefully. Coadministration of fentanyl with CYP3A4 inducers could lead on into a minimize in fentanyl plasma concentrations, insufficient efficacy or, maybe, advancement of the withdrawal syndrome within a affected individual that has here formulated physical dependence to fentanyl. Immediately after halting a CYP3A4 inducer, as the results of the inducer decrease, the fentanyl plasma concentration will boost which could increase or extend both of those the therapeutic and adverse results.